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In the latest study, the Yale researchers tested whether regular consumption of a mixture of five amino acids, known as the insulin-like growth factor 1 (IGF-1), had benefits. The compound is involved in insulin and growth hormone production.
After measuring the effects of the test-tube insulin to see whether it had an effect on insulin production, participants were given a diet containing a mixture of 10 amino acids. After the protein or a placebo, some of the amino acids did significantly increase insulin production. The study found no difference between the amino acids tested in the mixture and the compounds tested in supplements.
Researchers found significant effects in insulin and IGF-1 production because IGF-1 is produced by the pancreas itself, which is affected by diabetes. “The growth hormone-IGF-1 relationship may be the reason why insulin lowers the risk of diabetes in both type 2 and 1 diabetics,” said co-author Anthony Fauci, DrPH, an endocrinologist at Mount Sinai School of Medicine.
The researchers conducted a similar study of insulin from mice and found it to have similar effects compared to synthetic insulin. “We think, like with other drugs used to treat hyperinsulinemia, that the IGF-1 response to this synthetic mixture may work in humans but is much more complicated than our study shows,” said co-author Ronald Osterholm, MD, MD, the Harold W. Kravis Professor of Physiology in the Department of Human Pathology and Laboratory Medicine.
The test-tube test was conducted at Yale University; the study was published in the July 6 issue of the Journal of Clinical Investigation.
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